Dr. Alex Martinez于2017年加入生物系. 他来自圣埃利萨里奥, 他喜欢和妻子呆在一起, Natalina, and 3 kids, Arianna, Noah, and Annika.
- Ph.D. 生物医学科学, University of Texas Health Science Center at San Antonio (UTHSCSA) 生物医学科学 – Department of Pharmacology (2014), San Antonio, Texas
- Thesis Title: "Cannabinoid and peroxisome proliferator-activated receptors as anti-dyskinetic targets"
- 论文指导老师:Andrea Giuffrida博士.D.
- B.A. Biology, St. 玛丽大学(2004)，德克萨斯州圣安东尼奥
- Assistant Professor (Tenure-Track), 道成肉身的大学 (2017-Present), San Antonio, TX
- Visiting Assistant Professor, Trinity University (2013 - 2017), San Antonio, TX
- 副教授，圣. 玛丽大学(2012 - 2013)，德克萨斯州圣安东尼奥
- Guest Lecturer, Dental Hygiene Pharmacotherapeutics Course, UTHSCSA (2010), San Antonio,TX
- Part-time Instructor, Trinity University (2009), San Antonio, Texas.
- Guest Lecturer, Dental Hygiene Pharmacotherapeutics Course, UTHSCSA (2009), San Antonio, TX
研究经验
- Postdoctoral Fellow, UTHSCSA (2014- Present), San Antonio, TX
- Research Assistant, UTHSCSA (2004 - 2007), Laboratory of Dr. J. Roberts/Dr. A. 朱弗里达，圣安东尼奥，德克萨斯州
辅导经验
- 卡拉·卡莫纳，沃尔克学院澳门博彩官网下载，罗伯特·E. 李高中(2015- 2017)，圣安东尼奥，德克萨斯州
- 洁西卡电话, MBRS-RISE程序, 德克萨斯大学圣安东尼奥分校(2011 - 2012), San Antonio, TX
- Michelle Yuan, Summer Research Intern, Bard College (2010), Annandale-on-Hudson, NY
Presentations
- Drug Discovery in South Texas: Tapping into the Natural World for Solutions. 研讨会的椅子. SACNAS全国会议，圣安东尼奥，德克萨斯州. 2018年10月13日
- 帕金森病和左旋多巴诱导的运动障碍. 三一大学生物系系列讲座. 德克萨斯州圣安东尼奥三一大学. 2015年2月9日.
- 马丁内斯AA，皮萨努A，卡特A和朱弗里达A. Activation of PPAR gamma receptors reduces levodopa-induced dyskinesia without affecting L-DOPA and dopamine bioavailability in 6-OHDA-treated rats. (幻灯片演示)神经科学学会:638.07, 2011.
- Tackling the debilitating side effects of Parkinson’s Disease treatment: What can we learn from a rat model? 何塞·米格尔·西马德维拉纪念系列讲座. 玛丽大学，圣安东尼奥，德克萨斯州. 2010年10月29日.
Book Chapters
- 朱弗里达A和马丁内斯AA. 内源性大麻素系统与帕金森病. In: The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy. (E. Murillo-Rodriguez ed). Elsevier, Pp 63-81 (2017).
- 朱弗里达A和马丁内斯AA. 大麻素和左旋多巴诱导的运动障碍. In: Levodopa-induced Dyskinesia in Parkinson’s Disease (S. Fox, J. Brotchie, eds.). Springer, Pp 245-264 (2014).
Publications
- Martinez AA, Morgese MG, Pisanu A, Macheda T, Paquette MA, Seillier A, Cassano T, Carta AR和giffrida A. Activation of PPAR gamma receptors alleviates levodopa-induced dyskinesia in 6-OHDA-treated rats. Neurobiol Dis. 74(C):295-304 (2015). PMID: 2586547
- Seillier A, Martinez AA和Giuffrida A. Social withdrawal in Schizophrenia: lack of endocannabinoid-induced CB1 stimulation. 神经精神药理学38(9):1816-1824 (2013). PMID: 23563893
- Cheng B, Martinez AA, Morado J, Scofield V, Roberts JL and Maffi SK. Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway. Neurochem Int. 62(1):31-42 (2013). PMID: 23142153
- Paquette MA, Martinez AA, Macheda T, Meshul CK, Johnson SW, Berger SP and Giuffrida A. Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson’s disease: role of NMDA versus 5HT1A receptors. 【澳门博彩官网下载】. 36:3224-3234. (2012). PMID: 22861201
- Martinez A, Macheda T, Morgese MG, Trabace L and Giuffrida A. The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats. Neurosci Res. 72:236-242. (2012). PMID: 2219246
- Cheng B, Maffi SK, Martinez AA, Acosta YP, Morales LD and Roberts JL. Insulin-like growth factor-I mediates neuroprotection in proteasome inhibition-induced cytotoxicity in SH-SY5Y cells. Mol细胞神经科学. 2011;47:181-190. (2011). PMID: 21545837
- Price DA, Martinez AA, Seillier A, Koek W, Acosta Y, Fernandez E, Strong JR, Lutz B.， Marsicano G, Roberts JL和Giuffrida A. WIN55,212, 大麻素受体激动剂, protects against nigrostriatal cell loss in the MPTP mouse model of Parkinson’s disease. 【澳门博彩官网下载】. 29:2177-2186. (2009). PMID: 19490092
- 神经科学学会(SFN)(2007-至今)
- Center for Biomedical Neuroscience, UT Health San Antonio (2007-Present)
- Student member of the San Antonio Chapter of the SFN (2007-2012)
- Student member of the International Behavioral Neuroscience Society (IBNS)(2010)
- 2013 - Best Oral Presentation, 2013 Annual Terry Mikiten GSA Research Forum, UTHSCSA
- 2011 -药理学年度学生，UTHSCSA
- 2010 - Third place poster, 2010 Annual Terry Mikiten GSA Research Forum, UTHSCSA
- 2010 - Pharmacology Graduate Student 研讨会的椅子man, UTHSCSA
- 2009 - Pharmacology Graduate Student Symposium Co-Chairman, UTHSCS
- 2008 - Pharmacology Graduate Student Symposium Committee, UTHSCSA
- 2000-2004年总统奖学金，圣. 玛丽大学，圣安东尼奥，德克萨斯州
- 教练/志愿者, 天主教青年组织, 圣安东尼奥总教区(2018年至今), 德克萨斯州圣安东尼奥市
- 教师赞助商, uw SACNAS分会, SACNAS地方会议委员会(2018年至今), San Antonio, TX
- Word in Action, UIW Day of Service, Time Dollar Community Connections (2018), San Antonio, TX
- 8th Annual CORE4STEM Family Day, Exhibit Presenter, San Antonio College (2017), San Antonio, TX
The Martinez laboratory investigates novel targets in attenuating the unwanted side-effect in the treatment of Parkinson’s disease (PD) known as L-DOPA induced dyskinesia (LID). 使用帕金森病的大鼠模型, we are able mimic symptoms similar to LID and test various pharmacological compounds on whether they are able to decrease LID without affecting the therapeutic benefits of L-DOPA. Targets of interest that we investigate in decreasing LID include the endocannabinoid and peroxisome proliferator-activated receptor systems. 使用相同的验证大鼠PD模型, we are also investigating the relationship between traumatic brain injury and the development/progression of PD.
过往研究经费
F31ns073411-03, nih / ninds, 2011年1月- 2013年12月
Ruth L. Kirschestein National Research Service Award Individual Fellowship
项目名称: Validation of PPARgamma Agonists as Anti-Dyskinetic Drugs
Role: PI Description: Despite L-DOPA initial beneficial effects in treating Parkinson’s disease, its prolonged use results in the development of abnormal involuntary movements known as dyskinesia. Recent evidence suggests that activation of the nuclear receptor, PPARgamma, ameliorates these unwanted side effects once they are fully established. This proposal investigated whether co-administration of L-DOPA and a PPARgamma agonist (rosiglitazone) prevents the development of dyskinesias in a rodent model of Parkinson’s disease.
- 普通生物学(专业和实验室)
- BIOL 3202 Research Methods in Cell and Molecular Genetics
- bio4399st神经生理学读数